• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: FOX{D1,D2}.p2

Z-value: 2.040

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_+_145438437	44.627	NM_006472	TXNIP	thioredoxin interacting protein
chr5_-_42811959	43.006	NM_001085486 NM_001093726 NM_005410	SEPP1	selenoprotein P, plasma, 1
chr12_-_9268440	40.125		A2M	alpha-2-macroglobulin
chr12_-_92539614	37.941	NM_001731	BTG1	B-cell translocation gene 1, anti-proliferative
chr6_+_89791510	37.935		PNRC1	proline-rich nuclear receptor coactivator 1
chr12_-_9268513	37.260		A2M	alpha-2-macroglobulin
chrX_-_106960028	35.464		TSC22D3	TSC22 domain family, member 3
chr12_-_9268522	34.934	NM_000014	A2M	alpha-2-macroglobulin
chrX_-_106960268	33.880	NM_004089	TSC22D3	TSC22 domain family, member 3
chr22_-_31686707	33.479		PIK3IP1	phosphoinositide-3-kinase interacting protein 1
chr12_-_9268475	28.611		A2M	alpha-2-macroglobulin
chr11_-_117747331	28.539		FXYD6	FXYD domain containing ion transport regulator 6
chr17_-_29641068	27.366		EVI2B	ecotropic viral integration site 2B
chr10_-_45474210	27.357	NM_007021	C10orf10	chromosome 10 open reading frame 10
chr13_-_41240607	27.268	NM_002015	FOXO1	forkhead box O1
chr19_+_12902295	25.666	NM_002229	JUNB	jun B proto-oncogene
chr14_+_74551655	24.615	NM_001024674	LIN52	lin-52 homolog (C. elegans)
chr1_+_84630374	23.750		PRKACB	protein kinase, cAMP-dependent, catalytic, beta
chr1_+_117297056	23.238	NM_001767	CD2	CD2 molecule
chr5_-_131132642	22.992		FNIP1	folliculin interacting protein 1
chr10_-_90750955	22.584	NM_001141945	ACTA2	actin, alpha 2, smooth muscle, aorta
chr14_-_74551159	21.839	NM_005589	ALDH6A1	aldehyde dehydrogenase 6 family, member A1
chr11_+_73359734	21.481	NM_001130036	PLEKHB1	pleckstrin homology domain containing, family B (evectins) member 1
chr14_-_21493858	21.117		NDRG2	NDRG family member 2
chr5_-_169724614	20.937		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chrX_-_101112548	20.641	NM_032946	NXF5	nuclear RNA export factor 5
chr3_+_23987514	20.589	NM_001145425	NR1D2	nuclear receptor subfamily 1, group D, member 2
chr14_-_74551073	20.464		ALDH6A1	aldehyde dehydrogenase 6 family, member A1
chr14_-_21493910	20.445	NM_016250 NM_201535 NM_201536 NM_201537	NDRG2	NDRG family member 2
chr4_-_2263706	19.704	NM_006454	MXD4	MAX dimerization protein 4
chr6_+_122793061	19.678	NM_181794	PKIB	protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr22_-_31688329	19.404	NM_001135911 NM_052880	PIK3IP1	phosphoinositide-3-kinase interacting protein 1
chr14_+_24584009	18.851		DCAF11	DDB1 and CUL4 associated factor 11
chr1_-_92351613	18.176	NM_001195683 NM_003243	TGFBR3	transforming growth factor, beta receptor III
chr11_-_5255712	17.279	NM_000519	HBD	hemoglobin, delta
chr12_-_91576805	17.106	NM_001920	DCN	decorin
chr10_+_99079017	17.086	NM_005479	FRAT1	frequently rearranged in advanced T-cell lymphomas
chr17_-_29641094	17.018	NM_006495	EVI2B	ecotropic viral integration site 2B
chr17_-_29641087	16.959		EVI2B	ecotropic viral integration site 2B
chrX_+_70315637	16.958	NM_001170931 NM_005938	FOXO4	forkhead box O4
chr14_-_24584125	16.884		NRL	neural retina leucine zipper
chr16_+_77233348	16.548	NM_001129979	SYCE1L	synaptonemal complex central element protein 1-like
chr5_+_72251869	16.444
chr16_-_1832576	16.442	NM_080861	SPSB3	splA/ryanodine receptor domain and SOCS box containing 3
chr7_+_106809405	16.034	NM_001244262 NM_012257	HBP1	HMG-box transcription factor 1
chr5_-_169724782	16.005		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_+_227127993	15.857		ADCK3	aarF domain containing kinase 3
chr14_+_24584321	15.785		DCAF11	DDB1 and CUL4 associated factor 11
chr6_-_31550065	15.733	NM_002341 NM_009588	LTB	lymphotoxin beta (TNF superfamily, member 3)
chr7_+_134832765	15.607	NM_018295	TMEM140	transmembrane protein 140
chr1_+_227127959	15.514		ADCK3	aarF domain containing kinase 3
chr17_+_58755158	15.150	NM_001099432 NM_017679	BCAS3	breast carcinoma amplified sequence 3
chr17_-_66951381	14.971	NM_007168	ABCA8	ATP-binding cassette, sub-family A (ABC1), member 8
chr12_+_106696508	14.956	NM_152772	TCP11L2	t-complex 11 (mouse)-like 2
chr16_+_30484049	14.934		ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr7_-_140624280	14.903	NM_004333	BRAF	v-raf murine sarcoma viral oncogene homolog B1
chr18_-_53257033	14.848	NM_001243227 NM_001243228	TCF4	transcription factor 4
chr18_-_53303129	14.801	NM_001243226	TCF4	transcription factor 4
chr19_-_58609606	14.786	NM_001145543 NM_001145544 NM_023926	ZSCAN18	zinc finger and SCAN domain containing 18
chr22_-_38902344	14.681	NM_001098504 NM_006386	DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr19_-_58609574	14.397		ZSCAN18	zinc finger and SCAN domain containing 18
chr5_-_169724734	14.298		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr2_+_74120132	14.263		ACTG2	actin, gamma 2, smooth muscle, enteric
chr11_+_13299260	14.253	NM_001030272 NM_001030273 NM_001178	ARNTL	aryl hydrocarbon receptor nuclear translocator-like
chr10_+_99400469	14.243		PI4K2A	phosphatidylinositol 4-kinase type 2 alpha
chr11_-_65150107	14.242	NM_001077241 NM_182556	SLC25A45	solute carrier family 25, member 45
chr11_+_117049838	14.213	NM_001040455	SIDT2	SID1 transmembrane family, member 2
chr14_-_76447445	14.089		TGFB3	transforming growth factor, beta 3
chr14_-_91526912	14.046	NM_004755 NM_182398	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5
chr1_+_227127999	14.039		ADCK3	aarF domain containing kinase 3
chr9_-_3525973	14.029	NM_002919 NM_134428	RFX3	regulatory factor X, 3 (influences HLA class II expression)
chr2_+_97481977	13.991	NM_017623 NM_199078	CNNM3	cyclin M3
chr5_-_169724817	13.930	NM_005565	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr14_-_76448091	13.877	NM_003239	TGFB3	transforming growth factor, beta 3
chr7_-_17980102	13.691	NM_015132	SNX13	sorting nexin 13
chr16_+_30483959	13.640	NM_001114380 NM_002209	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr8_-_134309448	13.424	NM_001135242 NM_006096	NDRG1	N-myc downstream regulated 1
chr1_-_12677347	13.371	NM_004753	DHRS3	dehydrogenase/reductase (SDR family) member 3
chr15_+_81589240	13.359	NM_004513	IL16	interleukin 16
chr16_-_1832571	13.359		SPSB3	splA/ryanodine receptor domain and SOCS box containing 3
chr12_-_91576579	13.322		DCN	decorin
chr19_+_50380681	13.224	NM_001168222 NM_024682	TBC1D17	TBC1 domain family, member 17
chr2_+_74120092	13.195	NM_001199893 NM_001615	ACTG2	actin, gamma 2, smooth muscle, enteric
chr19_+_859658	13.160	NM_001928	CFD	complement factor D (adipsin)
chr11_+_13299391	13.110		ARNTL	aryl hydrocarbon receptor nuclear translocator-like
chr10_+_111985628	12.923	NM_005962	MXI1	MAX interactor 1
chr14_+_24583979	12.862	NM_025230	DCAF11	DDB1 and CUL4 associated factor 11
chr1_+_227127937	12.847	NM_020247	ADCK3	aarF domain containing kinase 3
chr14_-_75518132	12.788	NM_001040108 NM_014381	MLH3	mutL homolog 3 (E. coli)
chr9_-_135819995	12.762	NM_000368 NM_001162426 NM_001162427	TSC1	tuberous sclerosis 1
chr11_+_13299376	12.678		ARNTL	aryl hydrocarbon receptor nuclear translocator-like
chr11_+_13299372	12.668		ARNTL	aryl hydrocarbon receptor nuclear translocator-like
chrX_-_135863502	12.662	NM_004840	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr14_+_24583905	12.607	NM_001163484	DCAF11	DDB1 and CUL4 associated factor 11
chr16_+_55512801	12.587	NM_004530	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr16_-_4322695	12.540		TFAP4	transcription factor AP-4 (activating enhancer binding protein 4)
chr16_-_86542463	12.477		LOC400550	uncharacterized LOC400550
chr18_-_500583	12.368	NM_130386	COLEC12	collectin sub-family member 12
chr9_-_94124149	12.355		AUH	AU RNA binding protein/enoyl-CoA hydratase
chr1_-_92351476	12.311		TGFBR3	transforming growth factor, beta receptor III
chr20_+_23015949	12.283	NM_001052	SSTR4	somatostatin receptor 4
chr6_+_64345726	12.218		PHF3	PHD finger protein 3
chr19_+_859673	12.196		CFD	complement factor D (adipsin)
chr15_-_44828864	12.176
chr2_-_71454200	12.165	NM_020459	PAIP2B	poly(A) binding protein interacting protein 2B
chr11_+_13299349	12.047		ARNTL	aryl hydrocarbon receptor nuclear translocator-like
chr7_-_95225802	12.004	NM_002612	PDK4	pyruvate dehydrogenase kinase, isozyme 4
chr3_-_114343052	11.934	NM_001164347	ZBTB20	zinc finger and BTB domain containing 20
chr6_+_72922513	11.907	NM_001168407 NM_001168408	RIMS1	regulating synaptic membrane exocytosis 1
chr6_+_64345709	11.858		PHF3	PHD finger protein 3
chr10_+_111969988	11.844	NM_001008541	MXI1	MAX interactor 1
chr19_+_1205773	11.711	NM_000455	STK11	serine/threonine kinase 11
chr1_-_182357871	11.709		GLUL	glutamate-ammonia ligase
chr16_-_1832304	11.579		SPSB3	splA/ryanodine receptor domain and SOCS box containing 3
chr2_+_132480063	11.529	NM_013310	C2orf27A	chromosome 2 open reading frame 27A
chr13_-_36920396	11.523		SPG20	spastic paraplegia 20 (Troyer syndrome)
chr3_-_3221390	11.428	NM_001173482 NM_016302	CRBN	cereblon
chr6_+_64345672	11.409		PHF3	PHD finger protein 3
chr19_+_13875345	11.383		MRI1	methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr11_-_72504643	11.368	NM_006645	STARD10	StAR-related lipid transfer (START) domain containing 10
chr3_+_9691184	11.318		MTMR14	myotubularin related protein 14
chr3_-_3221361	11.311		CRBN	cereblon
chr3_-_3221385	11.278		CRBN	cereblon
chr17_-_42580745	11.099		GPATCH8	G patch domain containing 8
chr6_-_152623213	11.003		SYNE1	spectrin repeat containing, nuclear envelope 1
chr1_-_154840460	10.981
chr17_-_40897025	10.973	NM_001991	EZH1	enhancer of zeste homolog 1 (Drosophila)
chr22_-_38902315	10.945		DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr1_-_45956795	10.932	NM_007170	TESK2	testis-specific kinase 2
chr22_-_38902281	10.920		DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr1_-_115053677	10.778		TRIM33	tripartite motif containing 33
chr14_-_21493122	10.775	NM_201538 NM_201539 NM_201540 NM_201541	NDRG2	NDRG family member 2
chr5_+_176853673	10.747	NM_001004105 NM_001004106 NM_002082	GRK6	G protein-coupled receptor kinase 6
chr5_-_146435589	10.695	NM_181674 NM_181676	PPP2R2B	protein phosphatase 2, regulatory subunit B, beta
chr3_+_46411632	10.618	NM_000579 NM_001100168	CCR5	chemokine (C-C motif) receptor 5
chr3_+_147127151	10.471	NM_003412	ZIC1	Zic family member 1
chr5_-_64920100	10.464		TRIM23	tripartite motif containing 23
chr3_-_48956817	10.397	NM_001123040	C3orf71	chromosome 3 open reading frame 71
chr1_+_209878135	10.363	NM_005525	HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1
chr9_+_88897112	10.305
chr10_+_51549552	10.264	NM_002443 NM_138634	MSMB	microseminoprotein, beta-
chr20_+_48429375	10.213		SLC9A8	solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr3_+_9691116	9.985	NM_001077525 NM_001077526 NM_022485	MTMR14	myotubularin related protein 14
chr12_-_49504337	9.980		LMBR1L	limb region 1 homolog (mouse)-like
chr22_-_38902300	9.963		DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr11_+_10476665	9.955	NM_001025389	AMPD3	adenosine monophosphate deaminase 3
chr6_+_134758840	9.812		LOC154092	uncharacterized LOC154092
chr6_-_33168369	9.805	NM_021976	RXRB	retinoid X receptor, beta
chr13_+_79980420	9.757		RBM26-AS1	RBM26 antisense RNA 1 (non-protein coding)
chr15_-_40600118	9.755	NM_004573	PLCB2	phospholipase C, beta 2
chr11_+_63606535	9.730		MARK2	MAP/microtubule affinity-regulating kinase 2
chr17_+_65373923	9.695	NM_012417 NM_181671	PITPNC1	phosphatidylinositol transfer protein, cytoplasmic 1
chr17_+_77751929	9.593	NM_005189 NM_032647	CBX2	chromobox homolog 2
chr14_+_56585147	9.550		PELI2	pellino homolog 2 (Drosophila)
chr5_-_64920149	9.536	NM_001656 NM_033227 NM_033228	TRIM23	tripartite motif containing 23
chr1_-_182357757	9.430		GLUL	glutamate-ammonia ligase
chr7_-_115670774	9.371		TFEC	transcription factor EC
chr11_+_13299329	9.351		ARNTL	aryl hydrocarbon receptor nuclear translocator-like
chr7_-_76829109	9.269	NM_006682	FGL2	fibrinogen-like 2
chr7_-_37393271	9.241	NM_001206482	ELMO1	engulfment and cell motility 1
chr3_+_9691198	9.240		MTMR14	myotubularin related protein 14
chr12_+_96588254	9.226		ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)
chr15_+_99191671	9.177		IGF1R	insulin-like growth factor 1 receptor
chr12_+_12764755	9.148	NM_001310	CREBL2	cAMP responsive element binding protein-like 2
chr16_-_68033355	9.109	NM_022355	DPEP2	dipeptidase 2
chr5_+_169064238	9.105	NM_004946	DOCK2	dedicator of cytokinesis 2
chr17_-_80656461	9.025	NM_006822	RAB40B	RAB40B, member RAS oncogene family
chr2_+_12856813	8.977	NM_021643	TRIB2	tribbles homolog 2 (Drosophila)
chr19_-_50316360	8.926	NM_001171937 NM_025129	FUZ	fuzzy homolog (Drosophila)
chr11_+_63606346	8.756	NM_001039469 NM_001163296 NM_001163297 NM_004954	MARK2	MAP/microtubule affinity-regulating kinase 2
chr8_+_22133079	8.687	NM_001135721	PIWIL2	piwi-like 2 (Drosophila)
chr7_+_65419441	8.673		VKORC1L1	vitamin K epoxide reductase complex, subunit 1-like 1
chr6_+_111303240	8.663	NM_032194	RPF2	ribosome production factor 2 homolog (S. cerevisiae)
chr1_+_150122415	8.592		PLEKHO1	pleckstrin homology domain containing, family O member 1
chr2_-_198175324	8.571		ANKRD44	ankyrin repeat domain 44
chr7_-_17979998	8.495		SNX13	sorting nexin 13
chr8_+_22132809	8.465	NM_018068	PIWIL2	piwi-like 2 (Drosophila)
chrX_-_15333726	8.456	NM_001201583 NM_080873	ASB11	ankyrin repeat and SOCS box containing 11
chr14_-_23288912	8.440	NM_001126106	SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_-_20306908	8.422	NM_000300 NM_001161727 NM_001161728	PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)
chr3_-_12941547	8.421		IQSEC1	IQ motif and Sec7 domain 1
chr15_-_60884615	8.405	NM_134262	RORA	RAR-related orphan receptor A
chr11_+_63606598	8.361		MARK2	MAP/microtubule affinity-regulating kinase 2
chr8_-_127570465	8.219		FAM84B	family with sequence similarity 84, member B
chr1_+_150122095	8.204	NM_016274	PLEKHO1	pleckstrin homology domain containing, family O member 1
chr15_+_25230199	8.189		PAR5	Prader-Willi/Angelman syndrome-5
chr16_-_4323000	8.180	NM_003223	TFAP4	transcription factor AP-4 (activating enhancer binding protein 4)
chr1_+_150122246	8.116		PLEKHO1	pleckstrin homology domain containing, family O member 1
chr5_-_142065991	8.091	NM_033136	FGF1	fibroblast growth factor 1 (acidic)
chr6_+_139094656	8.008	NM_015439	CCDC28A	coiled-coil domain containing 28A
chr11_-_66335958	7.975	NM_003793	CTSF	cathepsin F
chr11_-_114466397	7.945		FAM55D	family with sequence similarity 55, member D
chr6_-_87804773	7.889	NM_000735 NM_001252383	CGA	glycoprotein hormones, alpha polypeptide
chr19_-_38720312	7.766	NM_001135156	DPF1	D4, zinc and double PHD fingers family 1
chr10_-_90712510	7.761	NM_001613	ACTA2	actin, alpha 2, smooth muscle, aorta
chr14_+_56584854	7.676	NM_021255	PELI2	pellino homolog 2 (Drosophila)
chr12_-_48213567	7.657	NM_001098416 NM_015401	HDAC7	histone deacetylase 7
chr16_-_57318574	7.623	NM_015993	PLLP	plasmolipin
chr17_+_38219040	7.615	NM_001190918 NM_003250 NM_199334	THRA	thyroid hormone receptor, alpha
chr19_+_57752051	7.599	NM_001023563 NM_001145078	ZNF805	zinc finger protein 805

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.26	1.35e-07	GO:0065007	biological regulation
1.71	2.55e-07	GO:0048583	regulation of response to stimulus
1.27	1.17e-06	GO:0050789	regulation of biological process
1.67	6.41e-06	GO:0007166	cell surface receptor linked signaling pathway
1.42	1.13e-05	GO:0023052	signaling
1.26	2.52e-05	GO:0050794	regulation of cellular process
2.12	2.65e-05	GO:0009890	negative regulation of biosynthetic process
2.13	2.84e-05	GO:0031327	negative regulation of cellular biosynthetic process
1.43	4.18e-05	GO:0007165	signal transduction
2.11	8.30e-05	GO:0010558	negative regulation of macromolecule biosynthetic process
1.52	9.38e-05	GO:0048519	negative regulation of biological process
2.10	2.27e-04	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
2.10	2.75e-04	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.08	4.18e-04	GO:0051172	negative regulation of nitrogen compound metabolic process
1.82	5.91e-04	GO:0006357	regulation of transcription from RNA polymerase II promoter
2.14	5.96e-04	GO:0051253	negative regulation of RNA metabolic process
2.14	7.66e-04	GO:0045892	negative regulation of transcription, DNA-dependent
1.84	8.93e-04	GO:0031324	negative regulation of cellular metabolic process
2.02	2.12e-03	GO:0010629	negative regulation of gene expression
2.28	2.32e-03	GO:0000122	negative regulation of transcription from RNA polymerase II promoter
1.48	2.42e-03	GO:0048523	negative regulation of cellular process
1.76	3.15e-03	GO:0009892	negative regulation of metabolic process
1.32	3.22e-03	GO:0051716	cellular response to stimulus
2.17	3.67e-03	GO:0050776	regulation of immune response
1.91	4.05e-03	GO:0002682	regulation of immune system process
1.41	4.62e-03	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.26	7.24e-03	GO:0032501	multicellular organismal process
1.22	1.86e-02	GO:0050896	response to stimulus
1.72	1.98e-02	GO:0010605	negative regulation of macromolecule metabolic process
1.37	2.67e-02	GO:0051171	regulation of nitrogen compound metabolic process
1.51	2.69e-02	GO:0023051	regulation of signaling
1.37	3.24e-02	GO:0009889	regulation of biosynthetic process
1.84	3.86e-02	GO:0007167	enzyme linked receptor protein signaling pathway
1.37	4.00e-02	GO:0031326	regulation of cellular biosynthetic process
1.77	4.10e-02	GO:0006955	immune response

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.52	1.94e-02	GO:0005887	integral to plasma membrane
1.50	3.69e-02	GO:0031226	intrinsic to plasma membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
2.10	6.40e-06	GO:0043565	sequence-specific DNA binding
1.85	1.81e-05	GO:0001071	nucleic acid binding transcription factor activity
1.85	1.81e-05	GO:0003700	sequence-specific DNA binding transcription factor activity
1.72	7.77e-04	GO:0030528	transcription regulator activity
2.21	1.14e-02	GO:0016564	transcription repressor activity
4.48	1.22e-02	GO:0003707	steroid hormone receptor activity
2.16	1.92e-02	GO:0016563	transcription activator activity
2.47	2.13e-02	GO:0000975	regulatory region DNA binding
2.47	2.13e-02	GO:0001067	regulatory region nucleic acid binding
2.47	2.13e-02	GO:0044212	transcription regulatory region DNA binding
4.23	2.15e-02	GO:0004879	ligand-dependent nuclear receptor activity
2.46	3.15e-02	GO:0010843	promoter binding