Motif ID: FOX{D1,D2}.p2

Z-value: 2.040


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
FOXD1 2297 forkhead box D1
FOXD2 2306 forkhead box D2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD1chr5_-_72744351-0.465.1e-13Click!
FOXD2chr1_+_479016880.343.6e-07Click!


Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_145438437 44.627 NM_006472
 TXNIP
thioredoxin interacting protein
chr5_-_42811959 43.006 NM_001085486
NM_001093726
NM_005410
 SEPP1


selenoprotein P, plasma, 1


chr12_-_9268440 40.125 A2M
alpha-2-macroglobulin
chr12_-_92539614 37.941 NM_001731
 BTG1
B-cell translocation gene 1, anti-proliferative
chr6_+_89791510 37.935 PNRC1
proline-rich nuclear receptor coactivator 1
chr12_-_9268513 37.260 A2M
alpha-2-macroglobulin
chrX_-_106960028 35.464 TSC22D3
TSC22 domain family, member 3
chr12_-_9268522 34.934 NM_000014
 A2M
alpha-2-macroglobulin
chrX_-_106960268 33.880 NM_004089
 TSC22D3
TSC22 domain family, member 3
chr22_-_31686707 33.479 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr12_-_9268475 28.611 A2M
alpha-2-macroglobulin
chr11_-_117747331 28.539 FXYD6
FXYD domain containing ion transport regulator 6
chr17_-_29641068 27.366 EVI2B
ecotropic viral integration site 2B
chr10_-_45474210 27.357 NM_007021
 C10orf10
chromosome 10 open reading frame 10
chr13_-_41240607 27.268 NM_002015
 FOXO1
forkhead box O1
chr19_+_12902295 25.666 NM_002229
 JUNB
jun B proto-oncogene
chr14_+_74551655 24.615 NM_001024674
 LIN52
lin-52 homolog (C. elegans)
chr1_+_84630374 23.750 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_117297056 23.238 NM_001767
 CD2
CD2 molecule
chr5_-_131132642 22.992 FNIP1
folliculin interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
2.28 2.32e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
2.17 3.67e-03 GO:0050776 regulation of immune response
2.14 5.96e-04 GO:0051253 negative regulation of RNA metabolic process
2.14 7.66e-04 GO:0045892 negative regulation of transcription, DNA-dependent
2.13 2.84e-05 GO:0031327 negative regulation of cellular biosynthetic process
2.12 2.65e-05 GO:0009890 negative regulation of biosynthetic process
2.11 8.30e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
2.10 2.27e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.10 2.75e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.08 4.18e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
2.02 2.12e-03 GO:0010629 negative regulation of gene expression
1.91 4.05e-03 GO:0002682 regulation of immune system process
1.84 8.93e-04 GO:0031324 negative regulation of cellular metabolic process
1.84 3.86e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.82 5.91e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.77 4.10e-02 GO:0006955 immune response
1.76 3.15e-03 GO:0009892 negative regulation of metabolic process
1.72 1.98e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.71 2.55e-07 GO:0048583 regulation of response to stimulus
1.67 6.41e-06 GO:0007166 cell surface receptor linked signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.52 1.94e-02 GO:0005887 integral to plasma membrane
1.50 3.69e-02 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
4.48 1.22e-02 GO:0003707 steroid hormone receptor activity
4.23 2.15e-02 GO:0004879 ligand-dependent nuclear receptor activity
2.47 2.13e-02 GO:0000975 regulatory region DNA binding
2.47 2.13e-02 GO:0001067 regulatory region nucleic acid binding
2.47 2.13e-02 GO:0044212 transcription regulatory region DNA binding
2.46 3.15e-02 GO:0010843 promoter binding
2.21 1.14e-02 GO:0016564 transcription repressor activity
2.16 1.92e-02 GO:0016563 transcription activator activity
2.10 6.40e-06 GO:0043565 sequence-specific DNA binding
1.85 1.81e-05 GO:0001071 nucleic acid binding transcription factor activity
1.85 1.81e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.72 7.77e-04 GO:0030528 transcription regulator activity